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Combination Therapy:

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Combination Therapy

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Combination Therapy
Rationale & Evidence
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Combination Medications
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Content created Mar 2002
Page updated 31 Aug 2005

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ForwardBackCombination medications 

Fluticasone and salmeterol (Seretide) 

Fluticasone propionate and salmeterol xinafoate are available as a combination medication delivered by CFC-free MDI and Accuhaler. The Accuhaler is suitable for patients who have coordination difficulties when using MDIs. 

  

Dosage:

MDI 50/25 : 50mcg fluticasone and 25mcg salmeterol 

MDI 125/25 : 125mcg fluticasone and 25mcg salmeterol 

MDI 250/25 : 250mcg fluticasone and 25mcg salmeterol 
 

Each MDI contains 120 doses.   
 

Adults and children > 12 years: two inhalations bd of MDI 50, 125 or 250 depending on the patient’s asthma severity
Children 4 years and over: two inhalations bd of MDI 50 
  

Accuhaler 100/50 : 100mcg fluticasone and 50mcg salmeterol 

Accuhaler 250/50 : 250mcg fluticasone and 50mcg salmeterol 

Accuhaler 500/50 : 500mcg fluticasone and 50mcg salmeterol 

  

Each Accuhaler contains 60 doses. 
    

Adults and children > 12 years: one inhalation bd of Accuhaler 100, 250 or 500, depending on the patient’s asthma severity.

  Children 4 years and over: one inhalation bd of Accuhaler 100 

  

Budesonide and eformoterol (Symbicort) 

Symbicort is a combination medication containing budesonide and eformoterol that is expected to be released in Australia in 2002. It is a dry powder delivered by Turbuhaler.