The leukotrienes are a family of pro-inflammatory mediators that play an important role in the pathophysiology of asthma. Leukotrienes are derived from cell membranes and released following activation of resident airway cells (mast cells) and infiltrating cells (eosinophils and neutrophils). They are involved in both early and late asthmatic airway responses to allergen challenge. Leukotrienes are potent bronchoconstrictors and also cause airway oedema, mucus secretion and recruitment of eosinophils into the airway. Leukotriene receptor antagonists bind to and inhibit specific receptors within the airway.

Montelukast (Singulair) is the only LTRA registered in Australia for use in children aged 2 and older. Montelukast is an orally active, specific LTRA that protects against early- and late-phase bronchoconstriction response to allergen challenge, and against exercise-induced bronchoconstriction.

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• Key points
• Introduction
• Diagnostic considerations in children
• Rationale for leukotriene antagonism in childhood asthma
• Dosage and administration
• Clinical evidence in children
• Other potential roles of LTRAs
• Acknowledgements
• References
• Appendices

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Leukotriene Receptor Antagonists in the Management of Childhood Asthma

Acknowledgements

This information paper was prepared in consultation with the following health professionals:

Professor Peter van Asperen, paediatric respiratory physician
Professor Craig Mellis, paediatric respiratory physician
Professor Colin Robertson, paediatric respiratory physician
Dr Kerry Hancock, general practitioner

Suggested Citation

National Asthma Council Australia. Leukotriene receptor antagonists in the management of childhood asthma. Melbourne: National Asthma Council Australia, 2010.

Disclaimer

Although all care has been taken, this information paper is a general guide only, which is not intended to be a substitute for assessment of appropriate courses of treatment on a case-by-case basis. The National Asthma Council Australia expressly disclaims all responsibility (including for negligence) for any loss, damage or personal injury resulting from reliance on the information contained herein.

Copyright

© 2010 National Asthma Council Australia