Dosage and Administration

Montelukast is administered once daily as a 4 mg (ages 2–5) or 5 mg (ages 6–14) chewable tablet, with or without food. The onset of therapeutic effects occurs within 1 day of commencing treatment.7 A study that examined the effect of montelukast at 2 and 12 hours in children with mild exerciseinduced asthma found that maximal effect occurs 12 hours after dosing.20

Studies in children with exercise-induced bronchoconstriction have demonstrated that equal protection against exerciseinduced asthma is achieved when montelukast is taken at night or in the morning.21