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How to use Fasenra pre-filled syringe

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If you and your doctor or nurse have decided that you can inject Fasenra (benralizumab) yourself, it is important that you know how to prepare and inject it properly.

This short video shows you how to use Fasenra prefilled syringe.

Ensure you read the ‘Instructions for Use’ carefully before using Fasenra prefilled syringe. You should receive training on how to use the prefilled syringe. Follow all directions given to you by your doctor or nurse carefully.

Checklist of steps

  1. Gather and set up on a clean, flat surface:
    • Fasenra pre-filled syringe (which may need to be removed from refrigerator)
    • Alcohol wipe
    • Cotton ball or gauze
    • Sharps disposal container
  2. Allow syringe to warm up at room temperature for about 30 minutes (if it has been in refrigerator)
  3. Check liquid through viewing window – it should be clear and colourless to yellow. It may contain small white particles and a small air bubble (do not use if liquid is cloudy, discoloured, or contains large particles)
  4. Choose injection site – this may be front of your thigh or lower part of your abdomen. A caregiver may also inject you in the upper arm (do not try to inject yourself in the arm). For each injection, use a different site at least 3 cm away from where you last injected
  5. Wash your hands with soap and water
  6. Clean injection site with alcohol wipe and let it air dry
  7. Remove needle cover from syringe*
  8. Hold syringe in one hand and use other hand to gently pinch skin surrounding injection site**
  9. Use a quick, dart-like motion to insert needle into pinched skin at a 45-degree angle
  10. Use thumb to push down on plunger head, until it is as far down as it will go
  11. Keep thumb pressed down as you take needle out of skin
  12. Slowly ease up on the plunger
  13. If there is a small amount of blood or liquid at the site, gently apply pressure to the area with a cotton ball or gauze and apply a Band-Aid if needed
  14. Dispose of used syringe in sharps disposal container
  15. Dispose of cap and other used supplies in household rubbish

*Hold syringe body while removing the needle cover (not plunger or plunger head)

**Do not press down on plunger until needle is completely inserted into skin or pull back on plunger at any time

Other important information

Other medicines

See our complete How-to video library for other injectable medicines and how to use them.


Thanks to Ms Ceri Banks, Asthma and Respiratory Educator, and the patient who participated in this film clip.

Development of this How-to video was supported by AstraZeneca Australia. The National Asthma Council Australia retained editorial control.


Although all care has been taken, this video is a general guide only, which is not a substitute for assessment of appropriate courses of treatment on a case-by-case basis. The National Asthma Council Australia expressly disclaims all responsibility (including for negligence) for any loss, damage or personal injury resulting from reliance on the information contained herein.